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To put it simply, yes it is

Symptoms include localised injection site redness and swelling, or systemic signs such as widespread hives, facial swelling, breathing difficulty, or cardiovascular collapse

Given that trypsin possesses distinct biochemical properties, structural features, and physiological context compared to TMPRSS2, it may not fully replicate the spatiotemporal regulation required for TMPRSS2-dependent spike proteolytic activation

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Versatile synthesis of bi- and tri-antennary galactose ligands: interaction with the Gal/GalNAc receptor of human hepatoma cells